Isotopically Labeled Compounds
Medchemexpress LLC Fingolimod-d4 | 1346747-38-3 | MFCD19704989 | 99.1% | 311.50 | 100 MG
Fingolimod-d4 is the deuterium labeled Fingolimod. It is a brain-penetrant sphingosine 1-phosphate (S1P) antagonist and also functions as a pak1 activator and an immunosuppressant. Deuterium labeling allows its use as a tracer for quantitation during drug development and has the potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Deuterium labeled
- Brain-penetrant sphingosine 1-phosphate (S1P) antagonist
- Pak1 activator
- Immunosuppressant
- Can be used as tracers for quantitation during drug development
- Potential to affect pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Ranolazine-d3 | 1054624-77-9 | 99.5% | 100 MG
Ranolazine-d3 is a deuterium labeled anti-angina agent that inhibits the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure. It also functions as a partial fatty acid oxidation inhibitor and is intended for research use only.
- Used as a tracer.
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC D-Glucose-d4 | 478529-49-6 | 99.0% | 50 MG
D-Glucose-d4 is the deuterium-labeled form of D-Glucose, an important monosaccharide and carbohydrate in biology. It serves as a critical signaling molecule and component of general metabolism. This compound can be utilized as a tracer and as an internal standard for quantitative analysis methods like NMR, GC-MS, or LC-MS.
- Used as a tracer.
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration has the potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Cefoperazone-d5 | 2410425-70-4 | 98.6% | 100 UG
Cefoperazone-d5 is deuterium labeled Cefoperazone. Cefoperazone, a semisynthetic cephalosporin, has a broad spectrum of antibacterial activity.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, primarily as tracers for quantitation during drug development.
- Deuteration is noted for its potential to impact the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Pimobendan-d3 | 74150-27-9 | 99.4% | 50 MG
Pimobendan-d3 (UD-CG115-d3) is deuterium labeled Pimobendan. It is a selective inhibitor of PDE3 with an IC50 of 0.32 μM. Deuterium labeled compounds are used as tracers for quantitation during drug development due to their potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- For research use only
Medchemexpress LLC Norgestrel-d6 | 2376035-98-0 | 99.5% | 5 MG
Norgestrel-d6 is the deuterium labeled Levonorgestrel, a synthetic progestogen used as an active ingredient in some hormonal contraceptives. It functions as a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. It is intended for research use only and can serve as a tracer or an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuterium labeled Levonorgestrel
- Synthetic progestogen
- Click chemistry reagent
- Contains an Alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- For use as a tracer or internal standard
- Suitable for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Naratriptan-d3 hydrochloride | 1190021-64-7 | 1 MG
Naratriptan-d3 is a deuterium labeled form of Naratriptan hydrochloride, a selective 5-HT1B/1D receptor agonist. This compound is peripherally active and exhibits good oral bioavailability, inducing cranial artery vasoconstriction. It also inhibits trigeminal nerve-mediated dural neurogenic plasma extravasation and reduces sterile inflammation, making it suitable for research into acute migraine, targeting cranial vascular and neuroinflammatory mechanisms.
- Used as a tracer
- Internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Acts as a selective 5-HT1B/1D receptor agonist
- Exhibits good oral bioavailability
- Induces cranial artery vasoconstriction
- Inhibits trigeminal nerve-mediated dural neurogenic plasma extravasation
- Reduces sterile inflammation
Medchemexpress LLC Pantothenic acid-13C3,15N hemicalcium | 356786-94-2 | 99.3% | 5 MG
Pantothenic acid-13C3,15N (hemicalcium) is the 13C-labeled and 15N-labeled D-Pantothenic acid. D-Pantothenic acid is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism.
- This compound can be used as a tracer.
- This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process.
- Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC D-Glucose-13C-5 | 106032-62-6 | >98.0% | 50 MG
D-Glucose-13C-5 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is a significant carbohydrate in biology. It serves as a carbohydrate sweetener and a critical component of general metabolism, also functioning as a crucial signaling molecule related to both cellular metabolic status and biotic and abiotic stress responses. Stable heavy isotopes, such as carbon-13, are incorporated into drug molecules for use as tracers in quantitative analysis during drug development.
- Labeled with 13C isotope
- Monosaccharide, significant carbohydrate in biology
- Functions as a crucial signaling molecule
- Used as a tracer in quantitative analysis
- Molecular formula C5¹³CH12O6
- Molecular weight 181.15
- Target: Endogenous Metabolite; Isotope-Labeled Compounds
- Pathway: Metabolic Enzyme/Protease; Others
- In Vitro Solubility: H2O: 30 mg/mL (165.61 mM; Need ultrasonic)
Medchemexpress LLC Piribedil-d8 | 1398044-45-5 | 99.8% | 1 MG
Piribedil-d8 is a deuterium-labeled analog of Piribedil, an antiparkinsonian agent known for its activity as a dopamine D2 and D3 agonist and α2-adrenoceptors antagonist. This compound serves as a valuable tracer and internal standard for quantitative analysis in various analytical techniques, including NMR, GC-MS, and LC-MS.
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis
- Acts as a dopamine D2 and D3 agonist
- Serves as an α2-adrenoceptors antagonist
- Inhibits MLL1 methyltransferase activity
- Potential for research in Parkinson's disease, circulatory disorders, and cancers
Medchemexpress LLC Demethoxycurcumin-d4 (Curcumin II-d4) | 22608-11-3 | 98.9% | 342.38 | 1 MG
Demethoxycurcumin-d4 is the deuterium labeled Demethoxycurcumin. Demethoxycurcumin (Curcumin II) is a major active curcuminoid with anti-inflammatory properties. It can be used as a tracer and an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Application as tracer
- Internal standard for quantitative analysis
- Deuterium substitution affects pharmacokinetic and metabolic profiles
Medchemexpress LLC Tropicamide-d3 | 2673270-13-6 | 99.1% | 5 MG
Tropicamide-d3 is the deuterium labeled form of Tropicamide. Tropicamide is a selective M4 muscarinic acetylcholine receptor antagonist that produces short-acting mydriasis and cycloplegia when applied as eye drops. Deuterium substitution in drug molecules is of interest due to its potential impact on pharmacokinetic and metabolic profiles.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Contains stable heavy isotopes for quantitation during drug development
- Deuteration may affect pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Methocarbamol-d3 | 1346600-86-9 | 98.2% | 1 MG
Methocarbamol-d3 is a deuterium-labeled form of Methocarbamol, an orally active central muscle relaxant. It functions by blocking the muscular Nav1.4 channel and reversibly influences the voltage dependence of its inactivation. It is valuable for research into muscle spasms and pain syndromes.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Eravacycline-d4 (dihydrochloride) | 100.0% | 635.50 | 500 UG
Eravacycline-d4 (TP-434-d4) dihydrochloride is a deuterium labeled Eravacycline, functioning as a potent and broad-spectrum antibacterial agent. It is designed for research use and can be utilized as a tracer or an internal standard.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes are incorporated for quantitation during drug development.
- Deuteration can affect pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Vericiguat-d3 hydrochloride | 1350653-20-1 | 99.8% | 465.86 | 5 MG
Vericiguat-d3 hydrochloride is a deuterated Vericiguat with tracer functionality. Vericiguat is an orally available stimulator of guanylate cyclase. This compound can be used as a tracer or as an internal standard for quantitative analysis.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS